hide

首页 / 封面设计

RhIII‐Catalyzed C−H Olefination of Benzoic Acids under Mild Conditions using Oxygen as the Sole Oxidant

Quandi Jiang Changlei Zhu Huaiqing Zhao Prof. Dr. Weiping Su

| First Published: 2016-02-04

Carboxyl‐directed ortho‐C−H functionalization of benzoic acids with alkenes occurs under mild conditions (60 °C) in the presence of 2.5 mol% Rh catalyst and a catalytic amount of carboxylic acid and base. This protocol uses abundant dioxygen as the sole oxidant, produces phthalides that are the core structure often found in natural products and pharmaceuticals, tolerates a broad range of functional groups, and allows for a variety of alkenes to participate in the reaction in good yields. The reaction is proposed to take place through carboxyl directed C−H olefination and subsequent Michael addition. More information can be found in the Communication by Huaiqing Zhao, Weiping Su et al. on page 356 in Issue 3, 2016 (DOI: 10.1002/asia.201500601).

回到顶部

联系我们

  • 地址

    辽宁省沈阳市铁西区北一西路52甲号830-06

  • 热线电话

    13236639606 或 13022406957

  • QQ

    客服1:1114371869 客服2:2501950479 客服3:1114371777

官方分享

辽公网安备21010602000232号

copyright © 2016 沈阳智研科技有限公司 版权所有网站建

沈阳网站建设:龙兴科技