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Neural Stem Cells: A Dual Functional Scaffold Tethered with EGFR Antibody Promotes Neural Stem Cell Retention and Neuronal Differentiation for Spinal Cord Injury Repair

Bai Xu Yannan Zhao Zhifeng Xiao Bin Wang Hui Liang Xing Li Yongxiang Fang Sufang Han Xiaoran Li Caixia Fan Jianwu Dai

| First Published: 2017-05-10

Jianwu Dai and co‐workers fabricate a dual functional collagen scaffold tethered with a collagen‐binding epidermal growth factor receptor (EGFR) antibody in article number 1601279. This scaffold can simultaneously attract neural stem cells (NSCs) and promote their neuronal differentiation after spinal cord injury by specifically binding to EGFR molecule expressed on NSCs and attenuating EGFR signaling, which is responsible for the inhibition of differentiation of NSCs toward neurons.

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