In article number 2001724, Chong Liu and co‐workers describe that the oncogenic state and cell identity need to match precisely to sensitize a glioma cell to IGF1R targeting. This phenomenon parallels the Chinese mortise and tenon joint structure, where different wood pieces are connected precisely by their mortise and tenon joints. Destruction of the mortise‐and‐tenon work (resembles the glioma hierarchy) needs the knowledge of how such structure is built up.

原文链接

https://onlinelibrary.wiley.com/doi/10.1002/advs.202070121