The front cover picture shows the generation of BODIPY turn‐on probes by introducing alkoxy tetrazines at the boron center of the BODIPY scaffold. This method endows the probes with the high water solubility and endows the bioorthogonal partner—TCO— with strongly fluorogenic properties. Using designed probes to detect TCO‐decorated antibodies on cells provides further insights into their application in live‐cell imaging. More information can be found in the full paper by H. Wu, P. Feng, et al. on page 530 in Issue 6, 2018 (DOI: 10.1002/cbic.201700556).