Prolonged immune activation via polymer–STING condensates

This issue highlights an albumin–IL-4 fusion protein that ameliorates experimental autoimmune encephalomyelitis, the potency of CAR-T cells targeting a nucleophosmin neoepitope for treating acute myeloid leukaemia, vaccination against leukaemia via the sustained release of co-encapsulated anti-PD-1 and a leukaemia-associated antigen, the generation of hypoimmunogenic T cells from engineered allogeneic human induced pluripotent stem cells, erythrocyte-anchored chemokine-encapsulating nanoparticles for treating lung metastases, the durable activation of innate immune pathways by a polyvalent STING agonist, and the design of host defence peptides that specifically target Mycobacterium tuberculosis.

The cover illustrates that a polymeric STING agonist can prolong the activation of innate-immunity pathways via the formation of condensates.

See Li et al. show less